Article
SLEPR: a sample-level enrichment-based pathway ranking method -- seeking biological themes through pathway-level consistency.
PloS one - 26 Sept 2008
Yi Ming, Stephens Robert M
Abstract excerpt
Analysis of microarray and other high throughput data often involves identification of genes consistently up or down-regulated across samples as the first step in extraction of biological meaning. This gene-level paradigm can be limited as a result of valid sample fluctuations and biological complexities. In this report, we describe a novel method, SLEPR, which eliminates this limitation by relying on...
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