Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

G0 function of BCL2 and BCL-xL requires BAX, BAK, and p27 phosphorylation by Mirk, revealing a novel role of BAX and BAK in quiescence regulation.

The Journal of biological chemistry - 5 Dec 2008

Janumyan Yelena, Cui Qinghua, Yan Ling, Sansam Courtney G, Valentin Mayda, Yang Elizabeth

Abstract excerpt

BCL2 and BCL-x(L) facilitate G(0) quiescence by decreasing RNA content and cell size and up-regulating p27 protein, but the precise mechanism is not understood. We investigated the relationship between cell cycle regulation and the anti-apoptosis function of BCL2 and BCL-x(L). Neither caspase inhibition nor abrogation of mitochondria-dependent apoptosis by BAX and BAK deletion fully recapitulated the G(0) effects...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to bcl-2-Associated X Protein
Share to bcl-2 Homologous Antagonist-Killer Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to bcl-X Protein

Share to Caspase 9

Share to Cyclin-Dependent Kinase Inhibitor p27

Share to Dyrk Kinases

Share to Protein-Tyrosine Kinases

Share to Proto-Oncogene Proteins c-bcl-2

Source

Open in PubMed Open full text

Identifiers

PMID: 18818203
DOI: 10.1074/jbc.M806294200
PMCID: PMC2590681

Genes

BAX
BCL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

G0 function of BCL2 and BCL-xL requires BAX, BAK, and p27 phosphorylation by Mirk, revealing a novel role of BAX and BAK in quiescence regulation.PMID 18818203Read ↗

Bcl-xL/Bcl-2 coordinately regulates apoptosis, cell cycle arrest and cell cycle entry.Semantic proximity Read ↗

Bcl2 retards G1/S cell cycle transition by regulating intracellular ROS.Semantic proximity Read ↗

Bcl2 at the endoplasmic reticulum protects against a Bax/Bak-independent paraptosis-like cell death pathway initiated via p20Bap31Semantic proximity Read ↗

Mcl-1 and Bcl-xL regulate Bak/Bax-dependent apoptosis of the megakaryocytic lineage at multistagesSemantic proximity Read ↗

The anti-apoptosis function of Bcl-2 can be genetically separated from its inhibitory effect on cell cycle entry.Semantic proximity Read ↗

Bcl-xL controls a switch between cell death modes during mitotic arrestSemantic proximity Read ↗

The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues.Semantic proximity Read ↗

BCLW mediates survival of postmitotic Sertoli cells by regulating BAX activity.Semantic proximity Read ↗

Expression of Bcl-2 and Bax in the Human Corpus Luteum during the Menstrual Cycle and in Early Pregnancy: Regulation by Human Chorionic Gonadotropin<sup>1</sup>Semantic proximity Read ↗

PGC-1α coordinates with Bcl-2 to control cell cycle in U251 cells through reducing ROSSemantic proximity Read ↗

BCR targets cyclin D2 via Btk and the p85alpha subunit of PI3-K to induce cell cycle progression in primary mouse B cells.Semantic proximity Read ↗

Bcl-x(S) anatagonizes the protective effects of Bcl-x(L).Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.