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Article

Bcl-xL/Bcl-2 coordinately regulates apoptosis, cell cycle arrest and cell cycle entry.

The EMBO journal - 15 Oct 2003

Janumyan Yelena M, Sansam Courtney G, Chattopadhyay Anuja, Cheng Ningli, Soucie Erinn L, Penn Linda Z, Andrews David, Knudson C Michael, Yang Elizabeth

Abstract excerpt

Bcl-x(L) and Bcl-2 inhibit both apoptosis and proliferation. In investigating the relationship between these two functions of Bcl-x(L) and Bcl-2, an analysis of 24 Bcl-x(L) and Bcl-2 mutant alleles, including substitutions at residue Y28 previously reported to selectively abolish the cell cycle activity, showed that cell cycle delay and anti-apoptosis co-segregated in all cases. In determining whether Bcl-2 and...

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Identifiers

PMID: 14532118
DOI: 10.1093/emboj/cdg533
PMCID: PMC213787

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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