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Article

The importance of gene dosage studies: mutational analysis of the parkin gene in early-onset parkinsonism.

Human molecular genetics - 1 Aug 2001

Hedrich K, Kann M, Lanthaler A J, Dalski A, Eskelson C, Landt O, Schwinger E, Vieregge P, Lang A E, Breakefield X O, Ozelius L J, Pramstaller P P, Klein C

Abstract excerpt

Early-onset parkinsonism (EOP) may be associated with different mutations in the parkin gene, including exon deletions and duplications. To test for gene dosage alterations, we developed a new method of quantitative duplex PCR using the fluorescence resonance energy transfer technique on the Ligh...

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Identifiers

PMID: 11487568
DOI: 10.1093/hmg/10.16.1649

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-11487568-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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