Article
Evaluation of 50 probands with early-onset Parkinson's disease for Parkin mutations.
Neurology - 23 Apr 2002
Hedrich K, Marder K, Harris J, Kann M, Lynch T, Meija-Santana H, Pramstaller P P, Schwinger E, Bressman S B, Fahn S, Klein C
Abstract excerpt
BACKGROUND: Early onset PD has been associated with different mutations in the Parkin gene, including exon deletions and duplications. METHODS: The authors performed an extensive mutational analysis on 50 probands with onset of PD at younger than 50 years of age. Thirteen probands were ascertained from a registry of familial PD and 37 probands by age at onset at younger than 50 years, blind to family history....
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