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Article

Exon dosage variations in Brazilian patients with Parkinson's disease: analysis of SNCA, PARKIN, PINK1 and DJ-1 genes.

Disease markers - 1 Jan 2012

Moura Karla Cristina Vasconcelos, Junior Mário Campos, de Rosso Ana Lúcia Zuma, Nicaretta Denise Hack, Pereira João Santos, José Silva Delson, Santos-Rebouças Cíntia Barros, Pimentel Márcia Mattos Gonçalves

Abstract excerpt

Parkinson's disease is one of the most common neurodegenerative disorders associated with aging, reaching ∼ 2% of individuals over 65 years. Knowledge achieved in the last decade about the genetic basis of Parkinson's disease clearly shows that genetic factors play an important role in the etiology of this disorder. Exon dosage variations account for a high proportion of Parkinson's disease mutations, mainly for...

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Identifiers

PMID: 22377733
DOI: 10.3233/DMA-2011-0873
PMCID: PMC3826582

Genes

PINK1
SNCA

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