Article
Compatibility among polymerase subunit proteins is a restricting factor in reassortment between equine H7N7 and human H3N2 influenza viruses.
Journal of virology - 1 Dec 2008
Li Chengjun, Hatta Masato, Watanabe Shinji, Neumann Gabriele, Kawaoka Yoshihiro
Abstract excerpt
Reassortment is an important driving force for influenza virus evolution, and a better understanding of the factors that affect this process could improve our ability to respond to future influenza pandemics and epidemics. To identify factors that restrict the generation of reassortant viruses, we cotransfected human embryonic kidney cells with plasmids for the synthesis of viral RNAs of both A/equine/Prague/1/56...
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