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Article

Reassortants with equine 1 (H7N7) influenza virus hemagglutinin in an avian influenza virus genetic background are pathogenic in chickens.

Virology - 1 Sept 1991

Banbura M W, Kawaoka Y, Thomas T L, Webster R G

Abstract excerpt

Reassortants possessing the hemagglutinin (HA) gene from A/Equine/London/1416/73 (H7N7) [Eq/Lond] and five or more genes from A/Chicken/Pennsylvania/1370/83 (H5N2) [Ck/Penn] were lethal in chickens. This result demonstrates that horses can maintain influenza viruses whose HAs are capable of promoting virulence. Thus, reassortment of equine and avian influenza virus genes could generate viruses that might be...

Topics

Amino Acid Sequence
Animals
Cell Line
Chick Embryo
Chickens
Genotype
Hemagglutinin Glycoproteins, Influenza Virus
Hemagglutinins, Viral
Horses
Influenza A Virus, H7N7 Subtype
Influenza A virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Viral Plaque Assay

Virulence

Source

Identifiers

PMID: 1871981
DOI: 10.1016/0042-6822(91)90872-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1871981-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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