Reassortment between Seasonal H1N1 and Pandemic (H1N1) 2009 Influenza Viruses Is Restricted by Limited Compatibility among Polymerase Subunits

Abstract excerpt

Reassortment is important for influenza virus evolution and the generation of novel viruses with pandemic potential; however, the factors influencing reassortment are still poorly understood. Here, using reverse genetics and a replicon assay, we demonstrated that a mixed polymerase complex containing a pandemic (H1N1) 2009 influenza virus PB2 on a seasonal H1N1 virus background has reduced polymerase activity,...

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