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Article

Murine coronaviruses encoding nsp2 at different genomic loci have altered replication, protein expression, and localization.

Journal of virology - 1 Dec 2008

Gadlage Mark J, Graham Rachel L, Denison Mark R

Abstract excerpt

Partial or complete deletion of several coronavirus nonstructural proteins (nsps), including open reading frame 1a (ORF1a)-encoded nsp2, results in viable mutant proteins with specific replication defects. It is not known whether expression of nsps from alternate locations in the genome can complement replication defects. In this report, we show that the murine hepatitis virus nsp2 sequence was tolerated in ORF1b...

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Identifiers

PMID: 18815297
DOI: 10.1128/JVI.01126-07
PMCID: PMC2583644

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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