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Article

Role of the HIV gp120 conserved domain 1 in processing and viral entry.

The Journal of biological chemistry - 21 Nov 2008

Wang Jizhen, Sen Jayita, Rong Lijun, Caffrey Michael

Abstract excerpt

The importance of the N-terminal region of HIV gp120 conserved domain 1 (gp120-C1) to envelope function has been examined by alanine-scanning mutagenesis and subsequent characterization of the mutagenic effects on viral entry; envelope expression, processing, and incorporation; and gp120 association with gp41. With respect to the wild-type gp120, mutational effects on viral entry fall into two classes:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18815131
DOI: 10.1074/jbc.M806099200
PMCID: PMC2583318

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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