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Article

Role of the HIV gp120 conserved domain 5 in processing and viral entry.

Biochemistry - 29 Jul 2008

Sen Jayita, Jacobs Amy, Caffrey Michael

Abstract excerpt

The importance of the HIV gp120 conserved domain 5 (gp120-C5) to envelope function has been examined by alanine scanning mutagenesis and subsequent characterization of the mutagenic effects on viral entry and envelope expression, processing, and incorporation, as well as gp120 association with gp41. With respect to the wild-type gp120, mutational effects on viral entry fall into three classes: (1) functional...

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Identifiers

PMID: 18597484
DOI: 10.1021/bi800227z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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