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Article

Functional analysis of the disulfide-bonded loop/chain reversal region of human immunodeficiency virus type 1 gp41 reveals a critical role in gp120-gp41 association.

Journal of virology - 1 Jul 2001

Maerz A L, Drummer H E, Wilson K A, Poumbourios P

Abstract excerpt

Human immunodeficiency virus type 1 (HIV-1) entry into cells is mediated by the surface-exposed envelope protein (SU) gp120, which binds to cellular CD4 and chemokine receptors, triggering the membrane fusion activity of the transmembrane (TM) protein gp41. The core of gp41 comprises an N-terminal triple-stranded coiled coil and an antiparallel C-terminal helical segment which is packed against the exterior of...

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Identifiers

PMID: 11413331
DOI: 10.1128/JVI.75.14.6635-6644.2001
PMCID: PMC114387

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