Ataxia-telangiectasia (A-T): An emerging dimension of premature ageing.

Abstract excerpt

A-T is a prototype genome instability syndrome and a multifaceted disease. A-T leads to neurodegeneration - primarily cerebellar atrophy, immunodeficiency, oculocutaneous telangiectasia (dilated blood vessels), vestigial thymus and gonads, endocrine abnormalities, cancer predisposition and varying sensitivity to DNA damaging agents, particularly those that induce DNA double-strand breaks. With the recent increase...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Aging, Premature
• Share to Ataxia Telangiectasia
• Share to Ataxia Telangiectasia Mutated Proteins