Article
Distinction of Plasmodium falciparum recrudescence and re-infection by MSP2 genotyping: a caution about unstandardized classification criteria.
Malaria journal - 23 Sept 2008
Rouse Petrica, Mkulama Mtawa Ap, Thuma Philip E, Mharakurwa Sungano
Abstract excerpt
BACKGROUND: Plasmodium falciparum genotyping with molecular polymorphic markers is widely employed to distinguish recrudescence from re-infection in antimalarial drug efficacy monitoring programmes. However, limitations occur on agarose gel DNA measurements used to resolve the polymorphisms. Without empirical data, the current distinction of pre- and post-treatment bands, as persistent or new infection, is...
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