Neighboring-site effects of amino acid mutation.

Abstract excerpt

Although the context dependence of nucleotide mutation has been supported by accumulating theoretical and experimental evidence, whether this effect can be extended to amino acid mutation remains obscure. As the amino acid doublets (20 x 20) are much more diverse than their nucleotide counterparts (4 x 4), any attempt to address the neighboring-site effects of amino acid mutation was frustrated by deficient amino...

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