Article
Model-driven analysis of experimentally determined growth phenotypes for 465 yeast gene deletion mutants under 16 different conditions.
Genome biology - 1 Jan 2008
Snitkin Evan S, Dudley Aimée M, Janse Daniel M, Wong Kaisheen, Church George M, Segrè Daniel
Abstract excerpt
BACKGROUND: Understanding the response of complex biochemical networks to genetic perturbations and environmental variability is a fundamental challenge in biology. Integration of high-throughput experimental assays and genome-scale computational methods is likely to produce insight otherwise unreachable, but specific examples of such integration have only begun to be explored. RESULTS: In this study, we measured...
Topics
- Gene Deletion
- Glycerol
- Models, Genetic
- Phenotype
- Raffinose
- Saccharomyces cerevisiae