Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Respiratory mutations lead to different pleiotropic effects on OXPHOS complexes in yeast and in human cells.

FEBS letters - 15 Oct 2008

Marsy Sophie, Frachon Paule, Dujardin Geneviève, Lombès Anne, Lemaire Claire

Abstract excerpt

Pleiotropic effects in the oxidative phosphorylation pathway (OXPHOS) were investigated in yeast respiratory mutants and in cells from patients with OXPHOS genetic alterations. The main differences between yeast and human cells were (1) the site of the primary defect that was associated with plei...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Respiration
Share to Cells, Cultured
Share to Child

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electron Transport Chain Complex Proteins

Share to Infant

Share to Mutation

Share to Oxidative Phosphorylation

Share to Saccharomyces cerevisiae

Source

Identifiers

PMID: 18804471
DOI: 10.1016/j.febslet.2008.09.016

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-18804471-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Respiratory mutations lead to different pleiotropic effects on OXPHOS complexes in yeast and in human cells.PMID 18804471Read ↗

Evaluation of the mitochondrial respiratory chain and oxidative phosphorylation system using yeast models of OXPHOS deficiencies.Semantic proximity Read ↗

Mutation detection in four candidate genes (OXA1L, MRS2L, YME1L and MIPEP) for combined deficiencies in the oxidative phosphorylation system.Semantic proximity Read ↗

Sym1, the yeast ortholog of the MPV17 human disease protein, is a stress-induced bioenergetic and morphogenetic mitochondrial modulator.Semantic proximity Read ↗

Mitochondrial dysfunction increases oxidative stress and decreases chronological life span in fission yeast.Semantic proximity Read ↗

The oncogenic RAS2(val19) mutation locks respiration, independently of PKA, in a mode prone to generate ROS.Semantic proximity Read ↗

Prenyldiphosphate synthase, subunit 1 (PDSS1) and OH-benzoate polyprenyltransferase (COQ2) mutations in ubiquinone deficiency and oxidative phosphorylation disorders.Semantic proximity Read ↗

Biochemical analysis of respiratory function in cybrid cell lines harbouring mitochondrial DNA mutations.Semantic proximity Read ↗

Cellular and functional analysis of four mutations located in the mitochondrial ATPase6 gene.Semantic proximity Read ↗

Developing a Novel and Optimized Yeast Model for Human VDAC Research.Semantic proximity Read ↗

Increased respiration in the sch9Delta mutant is required for increasing chronological life span but not replicative life span.Semantic proximity Read ↗

Respiratory deficiency in yeast mevalonate kinase deficient may explain MKD-associate metabolic disorder in humans.Semantic proximity Read ↗

Activation of Ras cascade increases the mitochondrial enzyme content of respiratory competent yeast.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.