Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The oncogenic RAS2(val19) mutation locks respiration, independently of PKA, in a mode prone to generate ROS.

The EMBO journal - 1 Jul 2003

Hlavatá Lydie, Aguilaniu Hugo, Pichová Alena, Nyström Thomas

Abstract excerpt

The RAS2(val19) allele, which renders the cAMP-PKA pathway constitutively active and decreases the replicative life-span of yeast cells, is demonstrated to increase production of reactive oxygen species (ROS) and to elevate oxidative protein damage. Mitochondrial respiration in the mutant is locked in a non-phosphorylating mode prone to generate ROS but this phenotype is not linked to a constitutively active PKA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cyclic AMP
Share to Cyclic AMP-Dependent Protein Kinases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Oncogene Protein p21(ras)

Share to Oxidative Stress

Share to Phosphorylation

Share to Reactive Oxygen Species

Share to Saccharomyces cerevisiae

Share to Valine

Source

Open in PubMed Open full text

Identifiers

PMID: 12839995
DOI: 10.1093/emboj/cdg314
PMCID: PMC165639

Genes

UCP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The oncogenic RAS2(val19) mutation locks respiration, independently of PKA, in a mode prone to generate ROS.PMID 12839995Read ↗

Mutations in signal transduction proteins increase stress resistance and longevity in yeast, nematodes, fruit flies, and mammalian neuronal cells.Semantic proximity Read ↗

Activation of Ras cascade increases the mitochondrial enzyme content of respiratory competent yeast.Semantic proximity Read ↗

Regulation of respiratory growth by Ras: the glyoxylate cycle mutant, cit2Delta, is suppressed by RAS2.Semantic proximity Read ↗

SOD2 functions downstream of Sch9 to extend longevity in yeast.Semantic proximity Read ↗

Increased respiration in the sch9Delta mutant is required for increasing chronological life span but not replicative life span.Semantic proximity Read ↗

Regulation of longevity and stress resistance by Sch9 in yeast.Semantic proximity Read ↗

Respiratory mutations lead to different pleiotropic effects on OXPHOS complexes in yeast and in human cells.Semantic proximity Read ↗

Ras mutants enhance the ability of cells to anticipate future lethal stressors.Semantic proximity Read ↗

Inactivation of Ymr1, Sjl2/3 phosphatases promotes stress resistance and longevity in wild type and Ras2G19V yeast.Semantic proximity Read ↗

Mutants in the Saccharomyces cerevisiae RAS2 gene influence life span, cytoskeleton, and regulation of mitosis.Semantic proximity Read ↗

Partial uncoupling of oxidative phosphorylation induces premature senescence in human fibroblasts and yeast mother cellsSemantic proximity Read ↗

Chronological aging-independent replicative life span regulation by Msn2/Msn4 and Sod2 in Saccharomyces cerevisiae.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.