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Article

The oncogenic RAS2(val19) mutation locks respiration, independently of PKA, in a mode prone to generate ROS.

The EMBO journal - 1 Jul 2003

Hlavatá Lydie, Aguilaniu Hugo, Pichová Alena, Nyström Thomas

Abstract excerpt

The RAS2(val19) allele, which renders the cAMP-PKA pathway constitutively active and decreases the replicative life-span of yeast cells, is demonstrated to increase production of reactive oxygen species (ROS) and to elevate oxidative protein damage. Mitochondrial respiration in the mutant is lock...

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Identifiers

PMID: 12839995
DOI: 10.1093/emboj/cdg314
PMCID: PMC165639

Genes

UCP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12839995-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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