Article
Activation of Ras cascade increases the mitochondrial enzyme content of respiratory competent yeast.
Biochemical and biophysical research communications - 24 May 2002
Dejean Laurent, Beauvoit Bertrand, Bunoust Odile, Guérin Bernard, Rigoulet Michel
Abstract excerpt
We investigated the effects of genetic and physiological modulations of the cAMP-protein kinase A pathway on mitochondrial biogenesis of yeast cells grown on lactate. Yeast mutants with over-activated Ras/adenylate cyclase pathway (i.e., Ras2(val19), ira1Delta(ira2)Delta) or with a constitutive downstream activation of protein kinases A (i.e., bcyDelta) showed an increase in the mitochondrial enzyme content. In...
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