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Article

IFN Consensus Sequence Binding Protein (Icsbp) Is Critical for Eosinophil Development

1 Oct 2008

Abstract excerpt

IFN consensus sequence binding protein (Icsbp) (IFN response factor-8) is a hematopoietic transcription factor with dual functions in myelopoiesis and immunity. In this study, we report a novel role of Icsbp in regulating the development of eosinophils. Loss of Icsbp in mice leads to a reduction of eosinophils in different tissues. During parasite infection with the nematode Nippostrongylus brasiliensis,...

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PMID: 18802108
DOI: 10.4049/jimmunol.181.7.5045

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