Article
Pathogenicity of Candida albicans auxotrophic mutants in experimental infections.
Infection and immunity - 1 Sept 1991
Kirsch D R, Whitney R R
Abstract excerpt
Auxotrophic and prototrophic control strain pairs of Candida albicans constructed by molecular biology methodologies were evaluated for pathogenicity in a systemic mouse model. Mutants that were auxotrophic for adenine, uracil, and heme each showed a lowered level of pathogenicity relative to control strains. It can be concluded from these experiments that decreased pathogenicity in each case is due to the...
Topics
- Animals
- Candida albicans
- Candidiasis
- Disease Models, Animal
- Female
- Genotype
- Mice
- Mutation
- Virulence