Article
Comparative pathogenicity of a wild-type strain and respiratory mutants of Candida albicans in mice.
Zentralblatt fur Bakteriologie : international journal of medical microbiology - 1 Aug 1990
Aoki S, Ito-Kuwa S, Nakamura Y, Masuhara T
Abstract excerpt
The pathogenicity of a parent wild-type strain and three respiratory mutants of Candida albicans was examined in intravenously infected mice. The wild-type strain K grew well in the kidney and caused severe candidosis, and the 21-day LD50 value was 7.2 x 10(6) cells/mouse. A mutant with a low rate of respiration (KRD-8) whose growth rate in vitro was somewhat lower than that of the wild type, produced germ tubes...
Topics
- Animals
- Body Weight
- Candida albicans
- Candidiasis
- Colony Count, Microbial
- Endopeptidases
- Kidney
- Liver
- Male
- Mice
- Mutation