Article
Pathogenicity of 5-fluorocytosine resistant strains of Candida albicans.
Journal of medical and veterinary mycology : bi-monthly publication of the International Society for Human and Animal Mycology - 1 Jan 1990
Fasoli M O, Kerridge D, Ryley J F
Abstract excerpt
Mutants of Candida albicans blocked in pyrimidine transport and salvage metabolism were produced by a two step mutagenic procedure and selected by their resistance to 5-fluorocytosine (flucytosine). The growth rates and growth yields of these mutants did not differ significantly from the parental strain of C. albicans. Examination of their pathogenicity to mice demonstrated that a defect in the uridine transport...
Topics
- Animals
- Candida albicans
- Candidiasis
- Drug Resistance, Microbial
- Flucytosine
- Kidney
- Kinetics
- Male
- Mice
- Mutation
- Virulence