Article
New powerful approaches for family-based association tests with longitudinal measurements.
Annals of human genetics - 1 Jan 2009
Ding Xiao, Lange Christoph, Xu Xin, Laird Nan
Abstract excerpt
We discuss several new powerful family-based approaches for testing genetic association when the traits are obtained from longitudinal or repeated measurement studies. The popular approach FBAT-PC is based on a linear combination of the individual traits. We propose a one-sided modification, FBAT-PCM, which has a closed-form expression and is always more powerful. We also present two approaches FBAT-LC and...
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