Article
High-density single nucleotide polymorphism screen in a large multiplex neural tube defect family refines linkage to loci at 7p21.1-pter and 2q33.1-q35.
Birth defects research. Part A, Clinical and molecular teratology - 1 Jun 2006
Stamm Demetra S, Rampersaud Evadnie, Slifer Susan H, Mehltretter Lorraine, Siegel Deborah G, Xie Jianzhen, Hu-Lince Diane, Craig David W, Stephan Dietrich A, George Timothy M, Gilbert John R, Speer Marcy C
Abstract excerpt
BACKGROUND: Neural tube defects (NTDs) are considered complex, with both genetic and environmental factors implicated. To date, no major causative genes have been identified in humans despite several investigations. The first genomewide screen in NTDs demonstrated evidence of linkage to chromosomes 7 and 10. This screen included 44 multiplex families and consisted of 402 microsatellite markers spaced...
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