Article
A role for planar cell polarity signaling in angiogenesis.
Angiogenesis - 1 Jan 2008
Cirone Pasquale, Lin Shengda, Griesbach Hilary L, Zhang Yi, Slusarski Diane C, Crews Craig M
Abstract excerpt
The planar cell polarity (PCP) pathway is a highly conserved signaling cascade that coordinates both epithelial and axonal morphogenic movements during development. Angiogenesis also involves the growth and migration of polarized cells, although the mechanisms underlying their intercellular communication are poorly understood. Here, using cell culture assays, we demonstrate that inhibition of PCP signaling...
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