Article
Identification of two late acyltransferase genes responsible for lipid A biosynthesis in Moraxella catarrhalis.
The FEBS journal - 1 Oct 2008
Gao Song, Peng Daxin, Zhang Wenhong, Muszyński Artur, Carlson Russell W, Gu Xin-Xing
Abstract excerpt
Lipid A is a biological component of the lipo-oligosaccharide of a human pathogen, Moraxella catarrhalis. No other acyltransferases except for UDP-GlcNAc acyltransferase, responsible for lipid A biosynthesis in M. catarrhalis, have been identified. By bioinformatics, two late acyltransferase genes, lpxX and lpxL, responsible for lipid A biosynthesis were identified, and knockout mutants of each gene in M....
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