Article
Moraxella catarrhalis bacterium without endotoxin, a potential vaccine candidate.
Infection and immunity - 1 Nov 2005
Peng Daxin, Hong Wenzhou, Choudhury Biswa P, Carlson Russell W, Gu Xin-Xing
Abstract excerpt
Lipooligosaccharide (LOS) is a major surface component of Moraxella catarrhalis and a possible virulence factor in the pathogenesis of human infections caused by this organism. The presence of LOS on the bacterium is an obstacle to the development of vaccines derived from whole cells or outer membrane components of the bacterium. An lpxA gene encoding UDP-N-acetylglucosamine acyltransferase responsible for the...
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