Article
Late acyltransferase genes lpxX and lpxL jointly contribute to the biological activities of Moraxella catarrhalis.
Journal of medical microbiology - 1 Jun 2013
Gao Song, Ren Dabin, Peng Daxin, Zhang Wenhong, Muszyński Artur, Carlson Russell W, Gu Xin-Xing
Abstract excerpt
Lipo-oligosaccharide (LOS) is a major surface component and virulence factor of the human respiratory pathogen Moraxella catarrhalis. Two late acyltransferase genes, lpxX and lpxL, have been identified involved in the incorporation of acyloxyacyl-linked secondary acyl chains into lipid A during M. catarrhalis LOS biosynthesis. In this study, a double mutant with a deletion of both the lpxX and lpxL genes in M....
Topics
- Acyltransferases
- Animals
- Antibodies, Bacterial
- Bacterial Proteins
- Blood Bactericidal Activity
- Female
- Humans
- Lipid A
- Lipopolysaccharides
- Mice
- Mice, Inbred BALB C
- Moraxella catarrhalis
- Moraxellaceae Infections