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Article

Identification of genetic variants using bar-coded multiplexed sequencing.

Nature methods - 1 Oct 2008

Craig David W, Pearson John V, Szelinger Szabolcs, Sekar Aswin, Redman Margot, Corneveaux Jason J, Pawlowski Traci L, Laub Trisha, Nunn Gary, Stephan Dietrich A, Homer Nils, Huentelman Matthew J

Abstract excerpt

We developed a generalized framework for multiplexed resequencing of targeted human genome regions on the Illumina Genome Analyzer using degenerate indexed DNA bar codes ligated to fragmented DNA before sequencing. Using this method, we simultaneously sequenced the DNA of multiple HapMap individuals at several Encyclopedia of DNA Elements (ENCODE) regions. We then evaluated the use of Bayes factors for...

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Identifiers

PMID: 18794863
DOI: 10.1038/nmeth.1251
PMCID: PMC3171277

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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