Multiplexed variation scanning for 1,000 amplicons in hundreds of patients using mismatch repair detection (MRD) on tag arrays.

doi:10.1073/pnas.0506677102

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Article

Multiplexed variation scanning for 1,000 amplicons in hundreds of patients using mismatch repair detection (MRD) on tag arrays.

Proceedings of the National Academy of Sciences of the United States of America - 11 Oct 2005

Faham Malek, Zheng Jianbiao, Moorhead Martin, Fakhrai-Rad Hossein, Namsaraev Eugeni, Wong Kee, Wang Zhiyong, Chow Shu G, Lee Liana, Suyenaga Kent, Reichert Jennifer, Boudreau Andrew, Eberle James, Bruckner Carsten, Jain Maneesh, Karlin-Neumann George, Jones Hywel B, Willis Thomas D, Buxbaum Joseph D, Davis Ronald W

Abstract excerpt

Identification of the genetic basis of common disease may require comprehensive sequence analysis of coding regions and regulatory elements in patients and controls to find genetic effects caused by rare or heterogeneous mutations. In this study, we demonstrate how mismatch repair detection on tag arrays can be applied in a case-control study. Mismatch repair detection allows >1,000 amplicons to be screened for...

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PMID: 16203980
DOI: 10.1073/pnas.0506677102
PMCID: PMC1253580

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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