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Article

Multiplex padlock targeted sequencing reveals human hypermutable CpG variations.

Genome research - 1 Sept 2009

Li Jin Billy, Gao Yuan, Aach John, Zhang Kun, Kryukov Gregory V, Xie Bin, Ahlford Annika, Yoon Jung-Ki, Rosenbaum Abraham M, Zaranek Alexander Wait, LeProust Emily, Sunyaev Shamil R, Church George M

Abstract excerpt

Utilizing the full power of next-generation sequencing often requires the ability to perform large-scale multiplex enrichment of many specific genomic loci in multiple samples. Several technologies have been recently developed but await substantial improvements. We report the 10,000-fold improvement of a previously developed padlock-based approach, and apply the assay to identifying genetic variations in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19525355
DOI: 10.1101/gr.092213.109
PMCID: PMC2752131

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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