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Article

IRAK4 kinase activity is redundant for interleukin-1 (IL-1) receptor-associated kinase phosphorylation and IL-1 responsiveness.

The Journal of biological chemistry - 18 Jun 2004

Qin Jinzhong, Jiang Zhengfan, Qian Youcun, Casanova Jean-Laurent, Li Xiaoxia

Abstract excerpt

Interleukin-1 (IL-1) stimulation leads to the recruitment of interleukin-1 receptor-associated kinase (IRAK) to the IL-1 receptor, where IRAK is phosphorylated, ubiquitinated, and eventually degraded. Kinase-inactive mutant IRAK is still phosphorylated in response to IL-1 stimulation when it is t...

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Source

Identifiers

PMID: 15084582
DOI: 10.1074/jbc.M400785200

Genes

IRAK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15084582-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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IRAK4 kinase activity is redundant for interleukin-1 (IL-1) receptor-associated kinase phosphorylation and IL-1 responsiveness.PMID 15084582Read ↗

The role of interleukin 1 receptor-associated kinase-4 (IRAK-4) kinase activity in IRAK-4-mediated signaling.Semantic proximity Read ↗

IRAK-4 kinase activity is required for interleukin-1 (IL-1) receptor- and toll-like receptor 7-mediated signaling and gene expression.Semantic proximity Read ↗

Interleukin 1/Toll-like receptor-induced autophosphorylation activates interleukin 1 receptor-associated kinase 4 and controls cytokine induction in a cell type-specific manner.Semantic proximity Read ↗

Mechanism of dysfunction of human variants of the IRAK4 kinase and a role for its kinase activity in interleukin-1 receptor signaling.Semantic proximity Read ↗

IRAK-4 kinase activity-dependent and -independent regulation of lipopolysaccharide-inducible genes.Semantic proximity Read ↗

The mechanism of activation of IRAK1 and IRAK4 by interleukin-1 and Toll-like receptor agonists.Semantic proximity Read ↗

IRAK1 Serves as a Novel Regulator Essential for Lipopolysaccharide-induced Interleukin-10 Gene ExpressionSemantic proximity Read ↗

The kinase activity of IL-1 receptor-associated kinase 4 is required for interleukin-1 receptor/toll-like receptor-induced TAK1-dependent NFkappaB activation.Semantic proximity Read ↗

The interleukin-1 receptor associated kinase 1 contributes to the regulation of NFAT.Semantic proximity Read ↗

Complete dependence on IRAK4 kinase activity in TLR2, but not TLR4, signaling pathways underlies decreased cytokine production and increased susceptibility to Streptococcus pneumoniae infection in IRAK4 kinase-inactive mice.Semantic proximity Read ↗

Mutant cells that do not respond to interleukin-1 (IL-1) reveal a novel role for IL-1 receptor-associated kinase.Semantic proximity Read ↗

Immune Complex-Mediated Cell Activation from Systemic Lupus Erythematosus and Rheumatoid Arthritis Patients Elaborate Different Requirements for IRAK1/4 Kinase Activity across Human Cell TypesSemantic proximity Read ↗

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