Article
IRAK-4 kinase activity is required for interleukin-1 (IL-1) receptor- and toll-like receptor 7-mediated signaling and gene expression.
The Journal of biological chemistry - 4 May 2007
Koziczak-Holbro Magdalena, Joyce Claire, Glück Anton, Kinzel Bernd, Müller Matthias, Tschopp Claude, Mathison John C, Davis Christopher N, Gram Hermann
Abstract excerpt
IRAK-4 is an essential component of the signal transduction complex downstream of the IL-1- and Toll-like receptors. Although regarded as the first kinase in the signaling cascade, the role of IRAK-4 kinase activity versus its scaffold function is still controversial. To investigate the role of IRAK-4 kinase function in vivo, "knock-in" mice were generated by replacing the wild type IRAK-4 gene with a mutant gene...
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