Article
Activation of human meningeal cells is modulated by lipopolysaccharide (LPS) and non-LPS components of Neisseria meningitidis and is independent of Toll-like receptor (TLR)4 and TLR2 signalling.
Cellular microbiology - 1 Mar 2005
Humphries Holly E, Triantafilou Martha, Makepeace Benjamin L, Heckels John E, Triantafilou Kathy, Christodoulides Myron
Abstract excerpt
The interactions of Neisseria meningitidis with cells of the meninges are critical to progression of the acute, compartmentalized intracranial inflammatory response that is characteristic of meningococcal meningitis. An important virulence mechanism of the bacteria is the ability to shed outer membrane (OM) blebs containing lipopolysaccharide (LPS), which has been assumed to be the major pro-inflammatory molecule...
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