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Cytoglobin, the Newest Member of the Globin Family, Functions as a Tumor Suppressor Gene

14 Sept 2008

Abstract excerpt

Cytoglobin (CYGB) is a recently discovered vertebrate globin distantly related to myoglobin with unknown function. CYGB is assigned to chromosomal region 17q25, which is frequently lost in multiple malignancies. Previous studies failed to detect evidence for mutations in the CYGB gene. Recent studies provided preliminary evidence for increased methylation of the gene in lung cancer. Our study was aimed at...

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PMID: 18794132
DOI: 10.1158/0008-5472.can-08-0565

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