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Article

A cell-specific regulatory region of the human ABO blood group gene regulates the neighborhood gene encoding odorant binding protein 2B.

Scientific reports - 1 Apr 2021

Sano Rie, Takahashi Yoichiro, Fukuda Haruki, Harada Megumi, Hayakawa Akira, Okawa Takafumi, Kubo Rieko, Takeshita Haruo, Tsukada Junichi, Kominato Yoshihiko

Abstract excerpt

The human ABO blood group system is of great importance in blood transfusion and organ transplantation. ABO transcription is known to be regulated by a constitutive promoter in a CpG island and regions for regulation of cell-specific expression such as the downstream + 22.6-kb site for epithelial cells and a site in intron 1 for erythroid cells. Here we investigated whether the + 22.6-kb site might play a role in...

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Identifiers

PMID: 33795748
DOI: 10.1038/s41598-021-86843-6
PMCID: PMC8016878

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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