Article

Loss of FANCD2 and related proteins may predict malignant transformation in oral epithelial dysplasia

2020-04-21

Abstract excerpt

<title>Abstract</title> <p>Background: Predicting malignant transformation in oral epithelial dysplasia(OED) is a clinical challenge. The higher rate of malignant transformation in non-smokers supports an endogenous aetiology. Loss of FANCD2 and associated proteins could lead to genomic instability and oncogenesis. <h4>Methods:</h4> Longitudinal archival samples from 40 individuals with OED from time of diagnosis...

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Literature Corpus work: 78fa0cc1-985a-5732-9de0-4e611baf9c71
DOI: 10.21203/rs.2.17496/v6

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