Article
Lack of association of the HbE variant with protection from cerebral malaria in Thailand.
Biochemical genetics - 1 Dec 2008
Naka Izumi, Ohashi Jun, Nuchnoi Pornlada, Hananantachai Hathairad, Looareesuwan Sornchai, Tokunaga Katsushi, Patarapotikul Jintana
Abstract excerpt
Hemoglobin E (HbE; beta26Glu --> Lys) is the most common variant of the beta-globin gene in Southeast Asia; it has been suggested that it confers resistance against Plasmodium falciparum malaria. In this study 306 adult patients with P. falciparum malaria (198 mild and 108 cerebral malaria patients) living in northwest Thailand were investigated to examine whether the HbE variant is associated with protection...
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