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Article

Trisomy 22 as the sole abnormality is an important marker for the diagnosis of acute myeloid leukemia with inversion 16.

Onkologie - 1 Sept 2008

Xu Wei, Zhou Hui-Fen, Fan Lei, Qian Si-Xuan, Chen Li-Juan, Qiu Hai-Rong, Zhang Su-Jiang, Li Jian-Yong

Abstract excerpt

BACKGROUND: The inversion of chromosome 16 (inv(16) (p13q22)) and the related t(16;16)(p13;q22) are chromosomal aberrations observed in approximately 10% of de novo acute myeloid leukemia (AML), mostly classified as M4Eo subtype, and associated with a relatively favorable outcome. However, it is a cryptic rearrangement and often difficult to recognize in conventional cytogenetics (CC). Trisomy 22 is an uncommon...

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Identifiers

PMID: 18787351
DOI: 10.1159/000141917

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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