Complex translocation (6;21;8), a variant of t(8;21), with trisomy 4 in a patient with acute myelogenous leukemia (M2).

doi:10.1016/s0165-4608(98)00121-6

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Article

Complex translocation (6;21;8), a variant of t(8;21), with trisomy 4 in a patient with acute myelogenous leukemia (M2).

Cancer genetics and cytogenetics - 1 Feb 1999

Shinagawa A, Komatsu T, Ninomiya H

Abstract excerpt

The t(8;21)(q22;q22) is the second-most frequently observed nonrandom karyotypic abnormality associated with acute myelogenous leukemia (AML), especially in FAB M2. Trisomy 4 is also a specific chromosomal abnormality for AML FAB M2 or M4. We experienced a 37-year-old woman with a morphologically...

Topics

Adult
Chromosome Banding
Chromosome Mapping
Chromosomes, Human, Pair 21
Chromosomes, Human, Pair 4
Chromosomes, Human, Pair 6
Chromosomes, Human, Pair 8
Core Binding Factor Alpha 2 Subunit
DNA-Binding Proteins
Female
Genetic Variation
Humans
Karyotyping
Leukemia, Myeloid, Acute
Proto-Oncogene Proteins
RNA, Messenger
RUNX1 Translocation Partner 1 Protein
Recombinant Fusion Proteins

Source

Open in PubMed

Identifiers

PMID: 9973964
DOI: 10.1016/s0165-4608(98)00121-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9973964-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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