Article
[Clinical and cytogenetic features of hematologic malignancies associated with acquired trisomy 21].
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics - 1 Oct 2008
Wang Huanping, Ni Wanmao, Chen Zhimei, Lou Jiyu, Xu Huan, Yu Yunbiao, Qian Wenbin, Jin Jie
Abstract excerpt
OBJECTIVE: To investigate the association between trisomy 21 abnormalities and the clinical and cytogenetic features of hematologic malignancies. METHODS: Chromosome preparations were made on bone marrow cells by using direct method and/or unstimulated short-term cultures. Karyotypes were analyzed by R-banding. RESULTS: Thirteen patients (1.5%) with acute myeloid leukemia (AML) including 6 cases of M5b, 8 (2.2%)...
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