Rifamycins do not function by allosteric modulation of binding of Mg2+ to the RNA polymerase active center.

doi:10.1073/pnas.0802822105

Article

Rifamycins do not function by allosteric modulation of binding of Mg2+ to the RNA polymerase active center.

Proceedings of the National Academy of Sciences of the United States of America - 30 Sept 2008

Feklistov Andrey, Mekler Vladimir, Jiang Qiaorong, Westblade Lars F, Irschik Herbert, Jansen Rolf, Mustaev Arkady, Darst Seth A, Ebright Richard H

Abstract excerpt

Rifamycin antibacterial agents inhibit bacterial RNA polymerase (RNAP) by binding to a site adjacent to the RNAP active center and preventing synthesis of RNA products >2-3 nt in length. Recently, Artsimovitch et al. [(2005) Cell 122:351-363] proposed that rifamycins function by allosteric modulation of binding of Mg(2+) to the RNAP active center and presented three lines of biochemical evidence consistent with...

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