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Article

Liver X Receptor Is a Therapeutic Target for Photoaging and Chronological Skin Aging

12 Sept 2008

Abstract excerpt

Liver X receptors (LXRalpha and -beta) are liposensors that exert their metabolic effects by orchestrating the expression of macrophage genes involved in lipid metabolism and inflammation. LXRs are also expressed in other tissues, including skin, where their natural oxysterol ligands induce keratinocyte differentiation and improve epidermal barrier function. To extend the potential use of LXR ligands to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 18787039
DOI: 10.1210/me.2008-0232

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