Article
Epidemiology and molecular biology of gastrointestinal stromal tumors (GISTs): a population-based study in the South of Switzerland, 1999-2005.
Histology and histopathology - 1 Nov 2008
Mazzola Paola, Spitale Alessandra, Banfi Sara, Mazzucchelli Luca, Frattini Milo, Bordoni Andrea
Abstract excerpt
Introduction. Gastrointestinal stromal tumors (GISTs) are characterized at the molecular level by c-kit or PDGFRA oncogene mutations. Although GISTs raised major interest in past decades, population-based studies are still rare. Materials and Methods. All GISTs diagnosed in Southern Switzerland (1999-2005) were identified using Ticino Cancer Registry and analysed for c-kit and PDGFRA mutations. Clinical and...
Topics
- Adult
- Aged
- Aged, 80 and over
- Exons
- Female
- Gastrointestinal Stromal Tumors
- Gene Expression Regulation, Neoplastic
- Humans
- Incidence
- Male
- Middle Aged
- Mutation
- Population Surveillance
- Proto-Oncogene Proteins c-kit