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Cyclin-Dependent Kinase Inhibitors as Anticancer Drugs

10 Feb 2010

Abstract excerpt

Poor therapeutic outcomes and serious side effects, together with acquired resistance to multiple drugs, are common problems of current cancer therapies. Therefore, there is an urgent need for new cancer-targeted drugs, which has led (inter alia) to the development of molecules that can specifically inhibit cyclin-dependent kinases (CDKs). In addition to their cell cycle regulatory functions, CDKs, especially...

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PMID: 20210754
DOI: 10.2174/138945010790711950

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