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Article

Autophagy genes protect against Salmonella typhimurium infection and mediate insulin signaling-regulated pathogen resistance.

Proceedings of the National Academy of Sciences of the United States of America - 25 Aug 2009

Jia Kailiang, Thomas Collin, Akbar Muhammad, Sun Qihua, Adams-Huet Beverley, Gilpin Christopher, Levine Beth

Abstract excerpt

A conserved insulin-like pathway modulates both aging and pathogen resistance in Caenorhabditis elegans. However, the specific innate effector functions that mediate this pathogen resistance are largely unknown. Autophagy, a lysosomal degradation pathway, plays a role in controlling intracellular bacterial pathogen infections in cultured cells, but less is known about its role at the organismal level. We examined...

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Identifiers

PMID: 19667176
DOI: 10.1073/pnas.0813319106
PMCID: PMC2731839

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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