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Article

A stereochemical test of a proposed structural feature of the nicotinic acetylcholine receptor.

Journal of the American Chemical Society - 8 Oct 2008

Hanek Ariele P, Lester Henry A, Dougherty Dennis A

Abstract excerpt

Understanding the gating mechanism of the nicotinic acetylcholine receptor (nAChR) and similar channels constitutes a significant challenge in chemical neurobiology. In the present work, we use a stereochemical probe to evaluate a proposed pin-into-hydrophobic socket mechanism for the alphaVal46 side chain of the nAChR. Utilizing nonsense suppression methodology we incorporated isoleucine (Ile), O-methyl...

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Identifiers

PMID: 18781739
DOI: 10.1021/ja8015457

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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