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Article

GATA-2 reinforces megakaryocyte development in the absence of GATA-1.

Molecular and cellular biology - 1 Sept 2009

Huang Zan, Dore Louis C, Li Zhe, Orkin Stuart H, Feng Gang, Lin Simon, Crispino John D

Abstract excerpt

GATA-2 is an essential transcription factor that regulates multiple aspects of hematopoiesis. Dysregulation of GATA-2 is a hallmark of acute megakaryoblastic leukemia in children with Down syndrome, a malignancy that is defined by the combination of trisomy 21 and a GATA1 mutation. Here, we show...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19620289
DOI: 10.1128/MCB.00482-09
PMCID: PMC2738300

Genes

GATA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19620289-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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